Polymorphism: C4A3


Variant Type: Haplotype
Location: 6p21.3

Factor:
- Symbol: C4A
- Name: complement component 4A (Rodgers blood group)
- Entrez ID: 120810
- Ensembl ID: ENSG00000244731

Factors:
  • C4A complement component 4A (Rodgers blood group) ( 120810 / ENSG00000244731 )


  • Description:

    No association with longevity. C4 alleles were examined in healthy aged people (77 centenarians and 89 elderly subjects). The frequencies of C4A alleles were similar in the studied cohorts. For C4B null allele (C4BQ0) a trend toward an increase in the older cohort was observed, although the differences were not statistically significant after correction for multiple testing.

    Ethnicity: Italian
    Age of cases: Mean age 101
    Finding: Negative

    Statistics
    - Number of cases/controls: 77 (cases) vs 235 (initial)
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: Restriction fragment analysis

    Reference:
    10219002: C4, BF, C3 allele distribution and complement activity in healthy aged people and centenarians.

    Choice: Curate
    Created: July 2, 2013, 2:33 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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