Polymorphism: XRCC5 120 bp 5` (GAPyA)n STR
Variant Type: STR
Location: 2q35
Factors:
XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
(
7520
/
ENSG00000079246
)
Description:
The [GAPyA]n microsatellite located 120 kb 5' of XRCC5 is significantly associated with longevity. It seems that it may be rs372249446.
Ethnicity:
British
Age of cases: Mean 70
Shorter lived allele: 16+2
Longer lived allele: 15
Finding: Positive
Statistics
- Number of cases/controls: 430 (case) vs 290 (initial)
- Odds ratio type: Longer
- p-value:
0.0005
- Significant: Yes
Study Design
- Classifications:
No Age Effect
- Study type: Candidate Region/Gene
- Technology: ABI Prism 310 Genetic Analyser
Reference:
16518718: Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity.
Choice: Clean
Created: July 2, 2013, 2:33 a.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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