Polymorphism: REN polymorphisms
Variant Type: SNP
Factor:
- Symbol: REN
- Name: renin
- Entrez ID: 5972
- Ensembl ID: ENSG00000143839
Description:
The research conducted used a "centenarian-only approach" rather than the traditional case-control design. And although a "significant interaction between REN gene allele 10 and the mitochondrial haplotype H, which could favour longevity," was found, the authors admitted that "[n]o effect of the gene alone can be estimated by this approach... [The centenarian-only approach] is limited to [gene-gene] interaction only.
Ethnicity:
Italian
Age of cases: 100+
Finding: Negative
Statistics
- Number of cases/controls: 157 (cases) (initial)
- Significant: No
Study Design
- Classifications:
No Age Effect
- Study type: Candidate Region/Gene
- Technology: N/A
Reference:
11938442: A centenarian-only approach for assessing gene-gene interaction in human longevity.
Choice: Clean
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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