Polymorphism: rs1800591-rs61733139
rs1800591-rs61733139 ( SNPedia | 23andMe )

Variant Type: Haplotype
Location: 4q24

Factor:
- Symbol: MTTP
- Name: microsomal triglyceride transfer protein
- Entrez ID: 4547
- Ensembl ID: ENSG00000138823

Factors:
  • MTTP microsomal triglyceride transfer protein ( 4547 / ENSG00000138823 )


  • Description:

    The two MTP polymorphisms are in complete LD. "We found no association of an MTP haplotype with longevity in either of our Leiden studies." Meta-analysis led to same conclusion.

    T-Q haplotype was studied. Initial number refers to offspring of nonagenarian sib pairs vs partners of offspring

    Ethnicity: Dutch
    Age of cases: Mean age 93.8±3.1
    Finding: Negative

    Statistics
    - Number of cases/controls: 197 vs 251 (initial)
    - p-value: 0.61 [0.61]
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: PCR based probes

    Reference:
    16611701: Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 9, 2014, 11:31 p.m.

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