Polymorphism: IL12B haplotypes



Location: 5q31.1-q33.1

Factor:
- Symbol: IL12B
- Name: interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
- Entrez ID: 3593
- Ensembl ID: ENSG00000113302

Factors:
  • IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) ( 3593 / ENSG00000113302 )


  • Description:

    "Analysis of IL-12B extended genotypes did not show any statistically significant associations despite of the slightly increased frequencies of (1188) C/C; (2124) A/A genotype in elderly... The functional relevance of the different distribution of this genotype remains to be clarified."

    Ethnicity: Italian, Bulgarian
    Age of cases: Age range: 65-99
    Longer lived allele: 1188 C/C, 2124 A/A

    Statistics
    - Number of cases/controls: 470 vs 120 (initial)
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: PCR-based sequencing

    Reference:
    21299522: 'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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