Polymorphism: IL10 haplotypes
Location: 1q31-q32
Factor:
- Symbol: IL10
- Name: interleukin 10
- Entrez ID: 3586
- Ensembl ID: ENSG00000136634
Factors:
IL10
interleukin 10
(
3586
/
ENSG00000136634
)
Description:
Interesting Note: "Additionally, in Bulgarians the IL-10 haplotype (−1082A, −819T, and −592A), possibly related to a lower level of gene expression, was found with slightly lower frequency in the elderly... The observations imply that longevity might be associated with anti-inflammatory cytokine gene profiles."
Ethnicity:
Bulgarian
Age of cases: Age range: 65-99
Longer lived allele: −1082G, −819C, -592C
Statistics
- Number of cases/controls: 60 vs 60 (initial)
- p-value:
0.05
[0.05]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR-based sequencing
Reference:
21299522: 'Immunogenetics of Aging': report on the activities of the 15th International HLA and Immunogenetics Working Group and 15th International HLA and Immunogenetics Workshop.
Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.
Edit
(
Admin) |
Delete
