Denigma Buck Institute Health Extension
Polymorphism: HLA-DQA1 haplotypes



Location: 6p21.3

Factor:
- Symbol: HLA-DQA1
- Name: major histocompatibility complex, class II, DQ alpha 1
- Entrez ID: 3117
- Ensembl ID: ENSG00000196735

Factors:
  • HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 ( 3117 / ENSG00000196735 )


    • Description:

    Alleles that were significant before but not after corrected P value test: Decreased in centenarians (HLA-DQA10102, HLA-DQA10103). Note: related to rs6457617?

    odds_ratio = RR = 2.508 (could not convert string to float: RR = 2.508)

    Ethnicity: Okinawan
    Age of cases: Mean age 102.3 +/- 1.9 years
    Shorter lived allele: non-HLA-DQA1*05 alleles
    Longer lived allele: HLA-DQA1*05

    Statistics
    - Number of cases/controls: 120 vs 129 (initial)
    - p-value: 0.038 [0.038]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology:

    Reference:
    9389323: Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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