Polymorphism: HLA-DQB1 haplotypes
Location: 6p21.3
Factor:
- Symbol: HLA-DQB1
- Name: major histocompatibility complex, class II, DQ beta 1
- Entrez ID: 3119
- Ensembl ID: ENSG00000179344
Factors:
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
(
3119
/
ENSG00000179344
)
Description:
The frequency of HLA-DQB10503 was significantly increased in the Okinawan centenarians compared to controls. Increased frequency can be explained by a LD with DRBl1401 or vice versa, which was also significantly frequent in them, because DRB11401-DQB10503-DQA1*0104 is one of the prominent haplotypes in Okinawan Japanese.
odds_ratio = RR = 5.196 (could not convert string to float: RR = 5.196)
Ethnicity:
Okinawan
Age of cases: Mean age 102.3 +/- 1.9 years
Shorter lived allele: non-DQB1*0503 alleles
Longer lived allele: DQB1*0503
Statistics
- Number of cases/controls: 120 vs 129 (initial)
- p-value:
0.0002
[0.0002]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology:
Reference:
9389323: Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity.
Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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