Denigma Buck Institute Health Extension
Polymorphism: many SNPs



Location: 11p15.5

Factor:
- Symbol: SIRT3
- Name: sirtuin 3
- Entrez ID: 23410
- Ensembl ID: ENSG00000142082

Factors:
  • SIRT3 sirtuin 3 ( 23410 / ENSG00000142082 )


    • Description:

    For the replication study, "eight SNPs were tested in a French sample (...mean [age] 51.2)... None of the earlier findings were confirmed in this analysis."

    Ethnicity: Italian
    Age of cases: Mean age 101.9 (southern Italian) | Mean age 101.0 (northern-central Italian) | Mean age 104.41 (German)

    Statistics
    - Number of cases/controls: 92 vs 97 (southern Italian) | 307 vs 352 (nothern-central Italian) | 376 vs 376 (German) (initial) | 546 vs 315 (replication)
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: SNPlex technology (Applied Biosystems)

    Reference:
    19367319: Human longevity and 11p15.5: a study in 1321 centenarians.

    Choice: Curate
    Created: July 1, 2013, 1:03 p.m.
    Updated: Aug. 26, 2013, 1:25 p.m.

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