Polymorphism: VNTR in intron 5 (DeltaEF1 site)
Location: 11p15.5
Factor:
- Symbol: SIRT3
- Name: sirtuin 3
- Entrez ID: 23410
- Ensembl ID: ENSG00000142082
Factors:
SIRT3
sirtuin 3
(
23410
/
ENSG00000142082
)
Description:
Results only applies to males. LD between the silent marker G47TT (identified in exon 3 of SIRT3) and VNTR
Ethnicity:
Italian
Age of cases: Median age 102
Shorter lived allele: 2b
Statistics
- Number of cases/controls: 242 vs 703 (initial)
- p-value:
8e-05
[8e-05]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: BigDye Terminator Cycle Sequencing Ready Reaction Kit (PE Applied Biosystems)
Reference:
15676284: A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.
Choice: Curate
Created: July 1, 2013, 1:03 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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