Denigma Buck Institute Health Extension
Polymorphism: rs13251813
rs13251813 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 8p12

Factor:
- Symbol: WRN
- Name: Werner syndrome, RecQ helicase-like
- Entrez ID: 7486
- Ensembl ID: ENSG00000165392

Factors:
  • WRN Werner syndrome, RecQ helicase-like ( 7486 / ENSG00000165392 )

    • Ethnicity: Danish
    Age of cases: 92-93 years old
    Shorter lived allele: G
    Longer lived allele: A
    Finding: Positive

    Statistics
    - Number of cases/controls: 1089 vs 736 (initial) | 1613 vs 1104 (replication)
    - Odds ratio: 1.84
    - p-value: 0.0002 [0.0002]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Illumina GoldenGate platform

    Reference:
    22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

    Choice: Curate_Emily
    Created: July 1, 2013, 10:47 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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