Polymorphism: HFE C282Y
Location: 6p21.3
Factor:
- Symbol: HFE
- Name: hemochromatosis
- Entrez ID: 3077
- Ensembl ID: ENSG00000010704
Factors:
HFE
hemochromatosis
(
3077
/
ENSG00000010704
)
Description:
Women carriers of C282Y mutation are at a higher frequency among the elderly compared with control women. Possession of C282Y allele, known to be associated with an increase of iron uptake, significantly increases women possibility to reach longevity [11857056].
Age of cases: 91-105 (< 50 versus >90)
Shorter lived allele: C
Longer lived allele: Y
Statistics
- Number of cases/controls: 35 vs 106 (initial)
- p-value:
7.2e-07
[7.2e-07]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR & gel electropheresis
Reference:
11857056: Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population.
Choice: Curate_Johnny
Created: July 1, 2013, 10:24 a.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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