Polymorphism: G477T
Location: 11p15.5
Factor:
- Symbol: SIRT3
- Name: sirtuin 3
- Entrez ID: 23410
- Ensembl ID: ENSG00000142082
Factors:
SIRT3
sirtuin 3
(
23410
/
ENSG00000142082
)
Description:
Only significant in males. TT increased with age (P=0.272), GT decreased (P=0.0391).
Ethnicity:
Italian
Age of cases: 120 subject aged 100 or older
Shorter lived allele: GT
Longer lived allele: TT
Statistics
- Number of cases/controls: 801 (initial)
- p-value:
0.0272
[0.0272]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR
Reference:
14580859: Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly.
Choice: Curate_Johnny
Created: July 1, 2013, 10:06 a.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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