Denigma Buck Institute Health Extension
Polymorphism: rs9536314
rs9536314 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 13q12

Factor:
- Symbol: KLOTHO
- Name: klotho
- Entrez ID: 9365
- Ensembl ID: ENSG00000133116

Factors:
  • KLOTHO klotho ( 9365 / ENSG00000133116 )


    • Description:

    Significant difference (p=0.008) in elderly (78 y.o., N=300) vs young (>66 y.o. N=463) in GA genotype, but not (p=0.426) in centenarian (>98.3 y.o. N=326) vs young (>66 y.o. N=463).

    Trivial name is KL-VS polymorphism or 1155G>A.

    Ethnicity: Italian
    Age of cases: >99.6
    Finding: Negative

    Statistics
    - Number of cases/controls: 326 (cases) vs 763 (initial)
    - Significant: No

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    19421891: The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect.

    Choice: Clean
    Created: July 1, 2013, 10:06 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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