Denigma Buck Institute Health Extension
Polymorphism: rs1800629
rs1800629 ( SNPedia | 23andMe )

Location: 6p21.3

Factor:
- Symbol: TNF
- Name: tumor necrosis factor
- Entrez ID: 7124
- Ensembl ID: ENSG00000232810

Factors:
  • TNF tumor necrosis factor ( 7124 / ENSG00000232810 )


    • Description:

    Significant in men only. Lower survival in A carriers (P=0.044) and decreased carrier frequency with increasing age (P=0.019).

    Ethnicity: Italian
    Age of cases: 19-110
    Shorter lived allele: A
    Longer lived allele: G

    Statistics
    - Number of cases/controls: 747 (initial)
    - p-value: 0.019 [0.019]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR & sequencing

    Reference:
    18511747: A genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G)-308 polymorphism.

    Choice: Curate_Johnny
    Created: July 1, 2013, 10:06 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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