Polymorphism: ADA genotypes



Location: 20q13.12

Factor:
- Symbol: ADA
- Name: adenosine deaminase
- Entrez ID: 100
- Ensembl ID: ENSG00000196839

Factors:
  • ADA adenosine deaminase ( 100 / ENSG00000196839 )


  • Description:

    Significant in males only. ADA*2 was decreased in males over age 85 but increased in those age 80-85 (relative to younger controls). Four groups are: Ages 90+, 86-90, 80-85, <70.

    Ethnicity: Italian
    Age of cases: Minimum age 90
    Shorter lived allele: ADA*2
    Longer lived allele: non-ADA*2

    Statistics
    - Number of cases/controls: 62 vs 64 vs143 vs 272 (initial)
    - p-value: 0.003 [0.003]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: RFLP-PCR

    Reference:
    20174870: Gender-specific association of ADA genetic polymorphism with human longevity.

    Choice: Curate_Johnny
    Created: July 1, 2013, 10:04 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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