Polymorphism: ADA genotypes
Location: 20q13.12
Factor:
- Symbol: ADA
- Name: adenosine deaminase
- Entrez ID: 100
- Ensembl ID: ENSG00000196839
Factors:
ADA
adenosine deaminase
(
100
/
ENSG00000196839
)
Description:
Significant in males only. ADA*2 was decreased in males over age 85 but increased in those age 80-85 (relative to younger controls). Four groups are: Ages 90+, 86-90, 80-85, <70.
Ethnicity:
Italian
Age of cases: Minimum age 90
Shorter lived allele: ADA*2
Longer lived allele: non-ADA*2
Statistics
- Number of cases/controls: 62 vs 64 vs143 vs 272 (initial)
- p-value:
0.003
[0.003]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: RFLP-PCR
Reference:
20174870: Gender-specific association of ADA genetic polymorphism with human longevity.
Choice: Curate_Johnny
Created: July 1, 2013, 10:04 a.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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