Denigma Buck Institute Health Extension
Polymorphism: rs4646994
rs4646994 ( SNPedia | 23andMe )

Variant Type: STR
Location: 17q23.3

Factor:
- Symbol: ACE
- Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- Entrez ID: 1636
- Ensembl ID: ENSG00000159640

Factors:
  • ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ( 1636 / ENSG00000159640 )


    • Description:

    ACE Alu D/I polymorphism. The D/D genotype is associated with mortality only in men. In a Chinese elderly population, ACE polymoprhism may be considered deleterious to longevity, the D/D genotype being associated with mortality, the atherosclerotic process, hypertension and myocarial_infarction. There are gender differences in the relationship between D/D genotype and cardivascular disease and mortality.

    Ethnicity: Chinese
    Age of cases: Minimum age 65
    Shorter lived allele: DD
    Finding: Positive

    Statistics
    - Number of cases/controls: 4000 (initial)
    - p-value: 0.05 [0.05]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR & gel electropheresis

    Reference:
    22456784: The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population.

    Choice: Clean
    Created: July 1, 2013, 10:04 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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