Polymorphism: 5-HTTLPR
Variant Type: Locus
Location: 17q11.2
Factor:
- Symbol: SLC6A4
- Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
- Entrez ID: 6532
- Ensembl ID: ENSG00000108576
Factors:
SLC6A4
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
(
6532
/
ENSG00000108576
)
Description:
Alleles can be long (L) or short (S).
The long-allele (L/L) genotype of the serotonin transporter-linked gene is more frequent in female centenarians than in male centenarians. Link to longevity not clear.
pvalue < 0.05
Genotype frequency were not at HWE P<0.05
Ethnicity:
Australian,
Caucasian
Age of cases: 101.0 ± 0.2
Shorter lived allele: L/L (only for males)
Finding: Positive
Statistics
- Number of cases/controls: 15 male, 53 female centenarians (cases) (initial)
- p-value:
0.03
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: PCR, gel electrophoresis
Reference:
22985157: Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians.
Choice: Clean
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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