Longevity DB

Polymorphism: apoE haplotypes






Description:

The distribution of APOE alleles in Greek adults appears to be similar to that observed in other southern European populations. APOE e4 allele frequency was found significantly lower in healthy individuals older than 80 years

gene symbol = APOE (get() returned more than one Factor -- it returned 2! Lookup parameters were {'symbol': u'APOE', 'entrez_gene_id': u'348', 'species': })

entrez gene id = 348 (get() returned more than one Factor -- it returned 2! Lookup parameters were {'symbol': u'APOE', 'entrez_gene_id': u'348', 'species': })

odds_ratio = N/A (could not convert string to float: )

Ethnicity: Greek
Age of cases: 80+
Shorter lived allele: Apo e4

Statistics
- Number of cases/controls: 80 vs 391 (initial)
- p-value: 0.02
- Significant: Yes

Study Design
- Study type: Candidate Region/Gene
- Technology: PCR, restriction digest, gel electrophoresis

Reference:
17234815: Lower prevalence of epsilon 4 allele of apolipoprotein E gene in healthy, longer-lived individuals of Hellenic origin.

Choice: Curate
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.

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