Polymorphism: rs2542052
rs2542052
(
SNPedia |
23andMe
)
Location: 11q23.3
Factor:
- Symbol: APOC3
- Name: apolipoprotein C-III
- Entrez ID: 345
- Ensembl ID: ENSG00000110245
Factors:
APOC3
apolipoprotein C-III
(
345
/
ENSG00000110245
)
Description:
The prevalence of homozygosity for the -641C allele in the APOC3 promoter (rs2542052) is higher in offspring of centenarians (20%) than in controls (10%).
Ethnicity:
Ashkenazi Jewish
Shorter lived allele: A
Statistics
- Number of cases/controls: 213 old vs 216 offspring vs 258 controls (initial)
- p-value:
0.001
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR
Reference:
16602826: Lipoprotein genotype and conserved pathway for exceptional longevity in humans.
Choice: Curate
Created: July 2, 2013, 1:11 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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