Polymorphism: REN polymorphism - mtDNA
Variant Type: Haplotype
Location: 1q32
Factor:
- Symbol: mtDNA
- Name: renin
- Entrez ID: 5972
- Ensembl ID: ENSG00000143839
Factors:
mtDNA
renin
(
5972
/
ENSG00000143839
)
Description:
A significant interaction between REN gene allele 10 and the mitochondrial H haplotype, which may favour longevity, was found. Both genes had been reported to exhibit no effect on survival alone. However, carriers of the two genes have a significantly increased probability of achieving a long life. Detailed OR information is as follows: 3.274 (1.405 ± 7.630)
Ethnicity:
Italian
Age of cases: 100+
Longer lived allele: REN10 - mtDNA haplogroup H
Finding: Positive
Statistics
- Number of cases/controls: 157 (initial)
- Odds ratio: 3.274
- Odds ratio type: Longer
- p-value:
0.006
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: N/A
Reference:
11938442: A centenarian-only approach for assessing gene-gene interaction in human longevity.
Choice: Clean
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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