The population study of the polymorphism at amino acid position 119 in the PCMT1 gene product included 395 unrelated individuals from the Los Angeles area, and 25 Norwegian and 20 Korean individuals. To ask if a correlation could be made between PCMT1 genotype and healthy aging in human populations, 40 Ashkenazi Jewish individuals (31 women and 9 men; 75-104 years old; average age, 87.2 years) were studied as representatives of a successfully aged population that were communicative, ambulatory, self-sufficient, and living independently in a retirement community. The codon 119 polymorphism was found to be associated with longevity [10496068].
Ethnicity: Ashkenazi Jewish