Polymorphism: (+)2019 del
Variant Type: Deletion
Location: 3q27
Factor:
- Symbol: ADIPOQ10
- Name: adiponectin, C1Q and collagen domain containing
- Entrez ID: 9370
- Ensembl ID: ENSG00000181092
Factors:
ADIPOQ10
adiponectin, C1Q and collagen domain containing
(
9370
/
ENSG00000181092
)
Description:
Over-representation of two common variants in Adiponectin gene (ADIPOQ) in male long-lived individuals combined with their independent association with elevated plasma adiponectin levels (in men and women) suggests that their presence may promote increased life span through the regulation of adiponectin production and/or secretion.
Ethnicity:
Ashkenazi Jewish
Age of cases: 95-105
Shorter lived allele: A
Longer lived allele: Del/Del
Finding: Positive
Statistics
- Number of cases/controls: 118 centenarians vs 78 unrelated young (initial)
- p-value:
0.05
[<0.05]
- Significant: Yes
Study Design
- Study type: Candidate Region/Gene
- Technology: Taqman, PSQ HS 96A Pyrosequencer
Reference:
18511746: Adiponectin levels and genotype: a potential regulator of life span in humans.
Choice: Clean
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
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