Polymorphism: SI000565Q
Variant Type: STR
Location: 2p24-p23
Factor:
- Symbol: APOB
- Name: apolipoprotein B (including Ag(x) antigen)
- Entrez ID: 338
- Ensembl ID: ENSG00000084674
Factors:
APOB
apolipoprotein B (including Ag(x) antigen)
(
338
/
ENSG00000084674
)
Description:
The study showed an allele-specific association between the 3'APOB-VNTR variability and lipidemic parameters in a southern Italian population. the observation that S alleles are rare in centenarians indicates that they are detrimental for longevity
Trivial name is 3'APOB VNTR.
Alleles are assigned as Long (L) or Short (S)
Ethnicity:
Italian
Age of cases: 100+
Shorter lived allele: S
Finding: Positive
Statistics
- Number of cases/controls: 70 (cases) vs 185 middle aged vs 174 young (initial)
- p-value:
[N/A]
Study Design
- Study type: Candidate Region/Gene
- Technology: PCR
Reference:
15028112: A study of the average effect of the 3'APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians.
Choice: Clean
Created: June 30, 2013, midnight
Updated: Aug. 8, 2014, 1:05 p.m.
Edit
(
Admin) |
Delete
