Denigma Buck Institute Health Extension
Polymorphism: rs28969505
rs28969505 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 1p35

Factor:
- Symbol: YTHDF2
- Name: YTH domain family, member 2
- Entrez ID: 51441
- Ensembl ID: ENSG00000198492

Factors:
  • YTHDF2 YTH domain family, member 2 ( 51441 / ENSG00000198492 )


    • Description:

    Summary: inter-Alu (TG)n polymorphism in YTHDF2 gene and its connection with healthy longevity.

    p-value = 0.047 (genotype), 0.014 (allele)

    Ethnicity: Italian
    Age of cases: Mean age 101
    Longer lived allele: 15-15 (205 bp)
    Finding: Positive

    Statistics
    - Number of cases/controls: 136 vs 275 (initial)
    - p-value: 0.047 [0.047 (genotype), 0.014 (allele)]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    16799135: A polymorphism of the YTHDF2 gene (1p35) located in an Alu-rich genomic domain is associated with human longevity.

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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