Denigma Buck Institute Health Extension
Polymorphism: rs4646994
rs4646994 ( SNPedia | 23andMe )

Alias: rs4340; rs1799752; rs13447447
Variant Type: Deletion
Location: 17q23.3

Factor:
- Symbol: ACE
- Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
- Entrez ID: 1636
- Ensembl ID: ENSG00000159640

Factors:
  • ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ( 1636 / ENSG00000159640 )


    • Description:

    This is an in/del polymorphism. The overall distributions of alleles in these three ethnic groups did not differ significantly. Within the Uighur group, frequency of the D allele was significantly higher in the very old group (0.448) than in the old group (.448),

    odds_ratio = N/A

    pvalue = .04

    Ethnicity: Chinese
    Age of cases: Old: 59-70, Very old 90-113
    Shorter lived allele: I (insertion)

    Statistics
    - Number of cases/controls: 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals (initial)
    - p-value: 0.04 [0.04 ]
    - Significant: Yes

    Study Design
    - Study type: Candidate Region/Gene
    - Technology: PCR, gel electrophoresis

    Reference:
    11773214: Angiotensin-converting enzyme gene and longevity in the Xin Jiang Uighur autonomous region of China: an association study.

    Choice: Curate
    Created: June 30, 2013, midnight
    Updated: Aug. 8, 2014, 1:05 p.m.

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