Denigma Buck Institute Health Extension
Polymorphism: rs4420638
rs4420638 ( SNPedia | 23andMe )

Location: 19q13.2

Factor:
- Symbol: APOC1
- Name: apolipoprotein C-I
- Entrez ID: 341
- Ensembl ID: ENSG00000130208

Factors:
  • APOC1 apolipoprotein C-I ( 341 / ENSG00000130208 )


    • Description:

    In LD with the APOE allele ɛ4

    pvalue = 1.8 x 10^-10 (invalid literal for float(): 1.8*10^-10)

    Ethnicity: German
    Age of cases: Mean age 99.7
    Shorter lived allele: G

    Statistics
    - Number of cases/controls: 763 vs 1085 (initial) | 754 vs 850 (replication)
    - Odds ratio: 0.53
    - p-value: [1.8 x 10^-10]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Genome-Wide Association Study
    - Technology: Affymetrix Genome-Wide Human SNP Array 6.0

    Reference:
    21740922: A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.

    Choice: Curate
    Created: July 2, 2013, 2:54 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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