Denigma Buck Institute Health Extension
Polymorphism: rs2291727
rs2291727 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 12q12-q13

Factor:
- Symbol: ADCY6
- Name: adenylate cyclase 6
- Entrez ID: 112
- Ensembl ID: ENSG00000174233

Factors:
  • ADCY6 adenylate cyclase 6 ( 112 / ENSG00000174233 )


    • Description:

    Re-Genotyping showed no differences in distribution between cases vs. controls.

    Ethnicity: Chinese
    Age of cases: Mean age 102.1±0.20
    Finding: Positive

    Statistics
    - Number of cases/controls: 384 vs 384 (initial) | 579 vs 644 (replication)
    - p-value: 0.003 [0.003]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Protocol of BigDye v1.1 kit and an ABI 3130XL sequencing system (Applied Biosystems)

    Reference:
    23020224: Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.

    Choice: Curate
    Created: July 2, 2013, 2:48 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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