Polymorphism: rs1042718-rs1042719
rs1042718-rs1042719 ( SNPedia | 23andMe )

Variant Type: Haplotype
Location: 5q31-q32

Factor:
- Symbol: ADRB2
- Name: adrenergic, beta-2-, receptor, surface
- Entrez ID: 154
- Ensembl ID: ENSG00000169252

Factors:
  • ADRB2 adrenergic, beta-2-, receptor, surface ( 154 / ENSG00000169252 )


  • Description:

    LD of rs1042718 & rs1042719

    Ethnicity: Chinese
    Age of cases: Mean age 102.1±0.20
    Shorter lived allele: G-C
    Longer lived allele: A-C
    Finding: Positive

    Statistics
    - Number of cases/controls: 384 vs 384 (initial) | 579 vs 644 (replication)
    - Odds ratio: 0.63
    - p-value: 1.86e-05 [1.86E-05]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Protocol of BigDye v1.1 kit and an ABI 3130XL sequencing system (Applied Biosystems)

    Reference:
    23020224: Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.

    Choice: Curate
    Created: July 2, 2013, 2:48 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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