Denigma Buck Institute Health Extension
Polymorphism: rs705649
rs705649 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 2q35

Factor:
- Symbol: XRCC5
- Name: X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
- Entrez ID: 7520
- Ensembl ID: ENSG00000079246

Factors:
  • XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) ( 7520 / ENSG00000079246 )


    • Description:

    Sig. in males. No OR mentioned, only β-coefficient = 4.669

    Ethnicity: Danish
    Age of cases: 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up
    Shorter lived allele: A - Unsure
    Finding: Positive

    Statistics
    - Number of cases/controls: 1089 (see notes - follow-up study) (initial) | 563 (see notes - follow-up study) (replication)
    - p-value: 0.029 [0.029]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene

    Reference:
    22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

    Choice: Curate
    Created: July 2, 2013, 2:48 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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