Denigma Buck Institute Health Extension
Polymorphism: rs13251813
rs13251813 ( SNPedia | 23andMe )

Location: 8p12

Factor:
- Symbol: WRN
- Name: Werner syndrome, RecQ helicase-like
- Entrez ID: 7486
- Ensembl ID: ENSG00000165392

Factors:
  • WRN Werner syndrome, RecQ helicase-like ( 7486 / ENSG00000165392 )

    • Ethnicity: Danish
    Age of cases: 92.2–93.8 (mean age 93.2
    Shorter lived allele: G

    Statistics
    - Number of cases/controls: 1089 vs 736 (initial) | 1613 vs 1104 (replication)
    - Odds ratio: 1.84
    - p-value: 0.0002 [0.0002]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene

    Reference:
    22406557: Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

    Choice: Curate
    Created: July 2, 2013, 2:48 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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