Polymorphism: rs73598374
rs73598374
(
SNPedia |
23andMe
)
Variant Type: SNP
Location: 20q13.12
Factor:
- Symbol: ADA
- Name: adenosine deaminase
- Entrez ID: 100
- Ensembl ID: ENSG00000196839
Factors:
ADA
adenosine deaminase
(
100
/
ENSG00000196839
)
Description:
Age class 1: Males(<66 years, N = 144) Females (<73 years, N = 191) Total: 335. Age class 2: Males (66–88 years, N = 261) Females (73–91 years, N = 285) Total: 546. Age class 3: Males (>88 years, N = 97) Females (>91 years, N = 93) Total: 190.
Applies to males only.
Ethnicity:
Italian
Age of cases: 66-88
Shorter lived allele: G*/G*
Longer lived allele: A*+
Finding: Positive
Statistics
- Number of cases/controls: 261 vs 144 (initial)
- Odds ratio: 1.943
- p-value:
0.036
[0.036]
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR
Reference:
21865054: Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy.
Choice: Curate
Created: July 2, 2013, 2:48 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.
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