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Longevity DB
Genetic variants implicated in human longevity.
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African European
Australian
Canadian
English People
Finn
Georgian
Human
Israeli
Multiethnic
Pomeranian
Sichuan
Spanish
Terraner
Age, Gene/Environment Susceptibility -Reykjavik Study Cohort (Island)
American
African American
American (Caucasian)
Amish
Atherosclerosis Risk Communities Study Cohort
Baltimore Longitudinal Study of Ageing Cohort
Cardiovascular Health Study Cohort
Caucasians (USA)
CHS (USA)
Framingham Heart Study Cohort
Framingham Heart Offspring Study Cohort
Gaucha population (Native South American)
Gerorgia (US)
New England American
North American
Mexican
Mexican Mestizo (see notes)
Study of Osteoporotic Fractures Cohort
The Health, Aging and Body Composition (USA)
US North European
USA (Black and European)
USA (Casucasians)
USA (Framington Heart Study)
Arab
Israelis
Nigerian
Tunisian
Turkish
Asian
Chinese
Bama Chinese
Chuang Chinese
Dujiangyan Han Chinese
Guangxi Bama Chinese
Han
Kahzak
Northern Chinese
Shanghai Chinese
Shenyang Chinese
Southern Chinese
Uyghur
Xinjiang Hetian Uyghur
Zhuang
Bama Zhuang
Japanese
Okinawan
Tokyo Japanese
Korean
Australian (Caucasian)
Australian centenarians of Caucasian ancestry
Brazilian
Gaucha Brazilian
Caucasian
Caucasian (NECS cohort)
Caucasian north
mostly Caucasian
European
African/European
British
English
Central European
Polish
Croatian
Danish
Dutch
Leiden Population
Rotterdam Population
Eastern European
European and Caucasian (many different european countries)
European Caucasian (Portuguese
European-origin (Caucasian)
French
German
Study of Health in Pomerania (Germany)
Greek
Irish
Belfast Irish
Northern Irish
Italian
Calabrian
Central Italian
Continental Italian
Invecchiare nel Chianti Cohort
Northeastern Italian
Northern Italian
Lombardy region Northern Italian
Northerncentral Italian
Sardinian
Southern Italian
Apulian
Calabrian
Northern European
Finns
Southern Finns
Tampere Population
Scottish
Southeastern Europe
Bulgarian
Southern European
Swiss
Western European
Spaniard
Caucasian Spanish
Caucasians from the city of Lleida in northeast Spain
Northern Spaniard
Spanish Combined: Pyrenees and Ebro’s Valley
Swedish
White European
Female
Caucasian Women
Georgia
Hispanic
Jewish
Ashkenazi Jewish
European-American Ashkenazi Jewish
Jordanian
Louisiana
Male
Mixed
Mixed Non-Hisp White
Slavs
Soviet
Russian
St. Petersburg Russian
Tatar
Tartarish
Population:
+
-
Canadian (1)
Finn (3)
Spanish (1)
Amish (2)
Chinese (10)
Japanese (2)
Caucasian (2)
Danish (1)
Dutch (1)
Italian (12)
Spaniard (5)
Ashkenazi Jewish (1)
Study type:
+
-
‑ (1)
Candidate Region/Gene (31)
Complete Mitochondrial Genome (1)
Mitochondrial Haplogroup (6)
Variant type:
+
-
Haplotype «
Variant effect:
+
-
Longevity‑Associated «
polymorphism
factor
odds ratio
pvalue
initial number
replication number
Population
age of cases
shorter lived allele
longer lived allele
study type
reference
rs1042718-rs1042719
ADRB2
0.63
1.86e-05
384 vs 384
579 vs 644
Chinese
Mean age 102.1±0.20
G-C
A-C
Candidate Region/Gene
23020224
APOE polymorphism
APOE
—
0.0001
291 vs 589
—
Finn
Mean age 97.5
e4
e2
Candidate Region/Gene
16487435
APOE haplotype - rs1346044
APOE
—
0.0001
175 vs 178
—
Finn
100.8
e4
e2
Candidate Region/Gene
10069711
mtDNA haplogroups
mtDNA
0.40
0.0003
74 vs 187
—
Amish
>80 years
J
non-J
Mitochondrial Haplogroup
21750925
rs1544410-rs17878969
VDR
15.30
0.001
104 vs 114
—
Caucasian
,
Spaniard
>85
non G-S haplotypes
G-S
Candidate Region/Gene
20407924
rs429358, rs7412
APOE
—
0.001
179 vs 615
—
Finn
Mean age 100
e4
e2, e3
Candidate Region/Gene
8018664
e4
APOE
0.35
0.001
729 vs 498
—
Japanese
100+
e4
—
Candidate Region/Gene
24534555
mtDNA haplogroups
mtDNA
7.56
0.0015
74 vs 187
—
Amish
>80 years
non-X
X
Mitochondrial Haplogroup
21750925
APOE polymorphism
APOE
0.38
0.002
200 (cases) vs 539
—
Italian
>88
e4
e2
Candidate Region/Gene
21703254
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581
CDKN1A
—
0.00211
184 vs 184
—
Italian
100
non G-G-G-C-C-G haplotypes
G-G-G-C-C-G
Candidate Region/Gene
20126416
rs3176343-rs3176344-rs3176349-rs1801270
CDKN1A
—
0.00394
184 vs 184
—
Italian
100
non G-G-G-C haplotypes
G-G-G-C
Candidate Region/Gene
20126416
apoE haplotypes
APOE
—
0.013
35 old vs 71 young vs 54 MI patients
—
Chinese
90
apoE4
ApT4
Candidate Region/Gene
11780357
apoE haplotypes
APOE
—
0.013
35 old vs 71 young vs 54 MI patients
—
Chinese
90
apoE4
—
Candidate Region/Gene
11780357
A-3826G (rs1800592) - C-3740A
UCP1
0.81
0.014
236 vs 741
—
Italian
>91
G-A
—
Candidate Region/Gene
21827845
rs1061581 - rs1008438 - rs2227956
Hsp70Ba
0.55
0.015
168 cases
—
Danish
Mean age 92.8 +/- 0.4
—
G-C-T (haplotype)
Candidate Region/Gene
20388090
rs1061581-rs1043618-rs2227956
—
4.51
0.016
191 vs 53
—
Chinese
>90
non A-G-C or non A-C-T haplotypes
A-C-T
Candidate Region/Gene
19840767
5417A,10873T
mtDNA
—
0.018
463 vs 1389
—
Chinese
>/=95
—
—
Mitochondrial Haplogroup
19641616
HP 1/2
HP
1.27
0.0194
1072 total
—
Italian
>88
HP*2
HP*1
Candidate Region/Gene
21147083
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581
CDKN1A
—
0.02249
184 vs 184
—
Italian
100
A-G-G-A-T-A
non A-G-G-A-T-A haplotypes
Candidate Region/Gene
20126416
rs11568820-rs4516035-rs10735810-rs1544410-rs17878969
VDR
11.50
0.024
104 vs 114
—
Caucasian
,
Spaniard
>85
G-G-C-G-S
non G-G-C-G-S haplotypes
Candidate Region/Gene
20407924
9 mtDNA haplogroups
mtDNA haplogroup
0.38
0.025
98 vs. 117
—
Chinese
90-100 years old
J
non-J
-
18759861
Haplogroup J
—
0.38
0.025
98 vs 117
—
Chinese
90–100
—
—
Candidate Region/Gene
18759861
rs429358, rs7412
APOE
—
0.025
(150 m, 74 f) vs (121 m, 320 f)
—
Ashkenazi Jewish
Mean age 75
e4
e2
Candidate Region/Gene
15621215
rs1061581-rs1043618-rs2227956
—
3.46
0.025
191 vs 53
—
Chinese
>90
non A-G-C or non A-C-T haplotypes
A-G-C
Candidate Region/Gene
19840767
mtDNA haplogroups
mtDNA
—
0.027
138
—
Spaniard
Minimum age 85
non-J
J
Mitochondrial Haplogroup
18931934
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25 of 39 variants
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