Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2075650 APOE 0.71 3.39e-17 403 vs 1670 4149 vs 7582 Dutch mean 94 e4 — Genome-Wide Association Study 21418511
rs970048 Intergenic 1.77 7.17e-07 3746 vs 5912 — Dutch Mean age 94 — G Genome-Wide Association Study 21418511
rs2498804 ATK1 0.75 0.001 403 vs 1670 4149 vs 7582 Dutch mean 94 A — Genome-Wide Association Study 21418511
rs11039149 NR1H3 — 0.015 599 — Dutch 85 years haplotype 1 haplotype 2 Candidate Region/Gene 17452725
rs12778366 SIRT1 0.69 0.025 1390 — Dutch 36 to 79 — — Candidate Region/Gene 23505545
rs1800591 MTTP — 0.032 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs2069827 IL6 — 0.064 1,089 vs 736 563 (longtitudinal study) Danish, Dutch 92+ Danish, 85+ Dutch A — — 22234866
rs662 PON1 1.06 0.11 — — Danish, Dutch, French, German, Italian, Tatar >/=80 — — Candidate Region/Gene 20362697
rs61733139 MTTP — 0.32 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs61733139 MTTP — 0.43 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
rs61733139 MTTP — 0.57 379 vs 251 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
rs1800591 MTTP — 0.6 379 vs 251 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs1800591 MTTP — 0.64 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
  • 15 variants