Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
HRAS1 LASS1 (CCT) APOE — 4.1e-05 147 vs 188 — Georgian — — — Candidate Region/Gene 20569235
rs6589722 — — 0.015 209 vs 402 — Japanese 95+ — — Candidate Region/Gene 23770741
rs1800591 MTTP — 0.032 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
rs1801274 FCGR2A — 0.05 408 vs 446 vs 454 — German 100–110/ mean101.3 (SNP is His/Arg) — Candidate Region/Gene 16893392
rs3745548 INSR — 0.057 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs708272 CETP — 0.068 523 vs 498 — Chinese Mean age 93.4 — — Candidate Region/Gene 22336474
rs11879589 PVRL2 1.67 0.07601 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
rs16944 IL1B — 0.08 250 vs 400 — Finn >90 — — Candidate Region/Gene 11640949
rs3176344 CDKN1A 0.40 0.08 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
rs17356414 JUN — 0.082 212 vs 401 — Japanese 95+ — — Candidate Region/Gene 23770741
rs2252673 INSR — 0.083 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
rs662 PON1 1.06 0.086 5086 vs 4269 — Irish >/=80 — — Candidate Region/Gene 20362697
rs419010 PVRL2 1.13 0.091 597 vs 1275 — Sichuan 90+ — — Candidate Region/Gene 24924924
rs2721044 FOXO1 0.90 0.097 1447 vs 1029 (German) 166 vs 216 (Italian) German — — — Candidate Region/Gene 21388494
rs876581 CDKN1A 0.58 0.103 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
rs3176343 CDKN1A 0.56 0.107 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
rs662 PON1 1.06 0.11 — — Danish, Dutch, French, German, Italian, Tatar >/=80 — — Candidate Region/Gene 20362697
rs2701859 FOXO1 0.90 0.117 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
rs189037 ATM 1.45 0.12 128 vs 150 — Italian Mean age 98.7 +/- 5.1 — — Candidate Region/Gene 22960875
rs2701880 FOXO1 0.83 0.12 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
rs12786104 CBL — 0.12 210 vs 398 — Japanese 95+ — — Candidate Region/Gene 23770741
rs10811661 — — 0.13 213 vs 402 — Japanese 95+ — — Candidate Region/Gene 23770741
rs11581271 FOXO6 0.91 0.131 1447 vs 1029 (German) 166 vs 216 (Italian) German Mean age 98.8 — — Candidate Region/Gene 21388494
rs3764650 ABCA7 — 0.135 1364 — American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
rs2053044 ADRB2 — 0.138 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 — — Candidate Region/Gene 23020224
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  • 25 of 209 variants