Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2251101 IDE 1.88 0.0011 829 vs 1033 — Australian, Caucasian Mixed — — Candidate Region/Gene 18448515
55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years — — Candidate Region/Gene 15050299
rs1685354 UCP3 — 0.762 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
rs647126 UCP3 — 0.447 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
SV-6 CLU — 1.0 49 vs 27 vs 20 — Greek, Italian 99–107 — — Candidate Region/Gene 16804001
rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833
rs1043618 HSP70-A1A — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
rs6457452 HSP70-A1B — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
rs708272 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
rs5882 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
H63D HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
S65C HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
rs3758391 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs1885472 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs2273773 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs10997870 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs2234975 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs1801274 FCGR2A — 1.0 408 vs 446 vs 454 — German Centenarians — — Candidate Region/Gene 16893392
rs854560 PON1 — 1.0 579 vs 308 — Italian Over 100 — — Candidate Region/Gene 12082503
192/55 loci PON1 — 0.01 579 vs 308 — Italian Over 100 — R+M+ Candidate Region/Gene 12082503
CYP2D6*3 CYP2D6 — 1.0 552 vs 243 — French mean 101 — — Candidate Region/Gene 9654200
CYP2D6*4 CYP2D6 — 1.0 523 vs 252 — French mean 101 — — Candidate Region/Gene 9654200
GSTM1 deletion GSTM1 — 1.0 565 vs 229 — French mean 101 — — Candidate Region/Gene 9654200
NAT2*5A (C 481 T), NAT2*6A (G 590 A), NAT2*7A (G 857 A), and NAT2*14A (G 191 A) NAT2 — 1.0 188 vs 88 — French mean 101 — — Candidate Region/Gene 9654200
rs189037 ATM — 0.004 875 vs 886 — Chinese mean 94.6 — CT Candidate Region/Gene 20816691
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  • 25 of 784 variants