polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
55 (L/M) | PON1 | 0.94 | 0.44 | 308 vs 579 Italian, 296 vs 296 Irish | — | Irish, Italian | Italian 100.8 years, Irish 89.8 years | — | — | Candidate Region/Gene | 15050299 |
192 (Q/R) | PON1 | 1.30 | 0.007 | 308 vs 579 Italian, 296 vs 296 Irish | — | Irish, Italian | Italian 100.8 years, Irish 89.8 years | Q | — | Candidate Region/Gene | 15050299 |
?60H | LMP2 | — | 0.756 | 157 vs 311 | — | Italian | 88+ | H | — | Candidate Region/Gene | 11772516 |
?145K | LMP7 | — | 0.849 | 157 vs 311 | — | Italian | 88+ | K | — | Candidate Region/Gene | 11772516 |
G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination | — | 3.19 | 0.0006 | 208 vs 514 | — | Italian | Mean age 96 | non-AAV allele combi | AAV allele combinati | Candidate Region/Gene | 21340542 |
rs2802288 | FOXO3A | 1.51 | 0.003 | 281 vs 195 | — | Italian | 90–108 | G | A | Candidate Region/Gene | 19415983 |
ADA genotypes | ADA | — | 0.003 | 62 vs 64 vs143 vs 272 | — | Italian | Minimum age 90 | ADA*2 | non-ADA*2 | Candidate Region/Gene | 20174870 |
rs1800629 | TNF | — | 0.019 | 747 | — | Italian | 19-110 | A | G | Candidate Region/Gene | 18511747 |
AAT M/Z/S | AAT | 0.18 | 1e-07 | 143 vs 255 vs 127 | — | Italian | Centenarians | M, S | Z | Candidate Region/Gene | 17048073 |
rs2069762 | IL-2 | 1.43 | 0.096 | 168 vs 214 | — | Italian | Centenarians | G | T | Candidate Region/Gene | 16518704 |
rs1805097 | IRS2 | 2.03 | 0.0003 | 144 vs 418 | — | Italian | 85-100 years old | non-AA | AA | Candidate Region/Gene | 19887537 |
APOA1-MspI-RFLP A/P alleles | APOA1 | — | 0.045 | 413 vs. 571 | — | Italian | median age 101 | A | P | Candidate Region/Gene | 12556235 |
rs662 | PON1 | — | 1.0 | 579 vs 308 | — | Italian | Over 100 | G | A | Candidate Region/Gene | 12082503 |
rs854560 | PON1 | — | 1.0 | 579 vs 308 | — | Italian | Over 100 | — | — | Candidate Region/Gene | 12082503 |
192/55 loci | PON1 | — | 0.01 | 579 vs 308 | — | Italian | Over 100 | — | R+M+ | Candidate Region/Gene | 12082503 |
codon 192 | PON1 | — | 1.0 | 192 vs 77 | — | Italian | 56 ages 66 to 89, 96 >90 | — | — | Candidate Region/Gene | 16799134 |
codon 55 | PON1 | — | 1.0 | 192 vs 77 | — | Italian | 56 ages 66 to 89, 96 >90 | — | — | Candidate Region/Gene | 16799134 |
Not specified | REN | — | 0.029 | 157 vs 218 | — | Italian | Centenarians | 11 | — | Candidate Region/Gene | 15105583 |
Not specified | IL2 | — | 0.05 | 470 vs 120 | — | Italian, Bulgarian | Age range: 65-99 | — | — | Candidate Region/Gene | 21299522 |
Not specified | IFNG | — | 0.05 | 707 vs 339 | — | Turkish, Polish, Italian, Bulgarian | Age range: 65-99 | — | — | Candidate Region/Gene | 21299522 |
−1082 G/A | IL10 | — | 0.025 | 190 vs 260 | — | Italian | >99 years old | — | G | Candidate Region/Gene | 11857058 |
VNTR (Variable Number of Tandem Repeats) | APOB | — | 0.003 | 143 vs 158 | — | Italian | mean age is 102 years | 35 or more tandem repeats | — | Candidate Region/Gene | 9050915 |
- | TH | — | 0.045 | 202 vs 170 vs 82 | — | Italian | 100-105 (oldest of 3 age groups, see notes) | — | — | Candidate Region/Gene | 11053670 |
3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR) | HRAS | 1.13 | 0.002 | 234 vs 467 | — | Italian | centenarians | a3 allele (see notes) | — | Candidate Region/Gene | 11943467 |
(A/C)−110 | HSP70-1 | 0.40 | 0.005 | 120 vs 471 | — | Italian | 100 years and above | A | — | Candidate Region/Gene | 14501185 |