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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
DR7 HLA-DRB1 0.01 325 centenarians versus 229 nonagenarian siblings French - 9425225
DR11 HLA-DRB1 0.01 325 centenarians versus 229 nonagenarian siblings French - 9425225
DR13 HLA-DRB1 0.01 325 centenarians versus 229 nonagenarian siblings French - 9425225
rs189037 ATM 1.85 0.028 128 vs 150 Italian - 22960875
MTP -493G/T MTP 0.854 Chinese - 23273182
R353Q FVII 0.61 113 vs 100 Scottish 96 years vs 32 years - 10744171
- GSTM1 0.74 94 vs 418 Italian 100 years vs 46 years - 11162685
rs429358, rs7412 APOE 0.009 1477 total Italian 18-109 e4 non-e4 - 16896546
GSTT1 gene deletion GSTT1 0.001 447 Danish 77.4 no deletion deletion - 16574194
rs1799814 CYP1A1 1.16 1.0 205 vs 294 German 80-89; reference group: 17-79 - 15177664
rs4646903 CYP1A1 1.03 0.23 205 vs 294 German 80-89; reference group: 17-79 - 15177664
rs1056836 CYP1B1 0.63 0.78 205 vs 294 German 80-89; reference group: 17-79 - 15177664
9 mtDNA haplogroups mtDNA haplogroup 0.38 0.025 98 vs. 117 Chinese 90-100 years old J non-J - 18759861
IVS7 FVII 0.69 113 vs 100 Scottish 96 vs 32 - 10744171
STR variation CSF1TPO 0.003 60 vs 250 Chinese >90 low variation in STRs high variation in STRs - 20582731
F5 G1691A F5 0.002 400 neonates (187 female and 312 male), 184 healthy adults (129 female and 55 male), and 432 long-lived individuals (343 women and 89 men). Polish >95 years versus 44 years - 20720309
- HRAS1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes - 19367319
- SIRT3 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- TH 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- INS 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- IGF2 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4073591 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4073590 DEAF1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs11040489 KRTAP5-6 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4930001 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
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