Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs5491 ICAM1 — 5e-66 5036 — American 28-70 TT, AT AA Genome-Wide Association Study 22174011
rs9330200 TUBB4B — 6e-53 5036 — American 28-70 AA, AT TT Genome-Wide Association Study 22174011
rs2292664 RIMBP2 — 1.4e-37 5036 — American 28-70 CC, CG GG Genome-Wide Association Study 22174011
rs2075650 APOE 0.71 3.39e-17 403 vs 1670 4149 vs 7582 Dutch mean 94 e4 — Genome-Wide Association Study 21418511
rs1528753 — — 8.1e-08 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs4420638 APOE — 9.6e-08 4445 total (each a part of sibship of 2-5 siblings) — Caucasian, European 90 — — Genome-Wide Association Study 23286790
rs3129046 — 0.66 2.21e-07 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
rs1610742 — 0.66 3.02e-07 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
rs970048 Intergenic 1.77 7.17e-07 3746 vs 5912 — Dutch Mean age 94 — G Genome-Wide Association Study 21418511
rs10493513 — — 1.5e-06 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs1610601 — 0.68 1.98e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
rs2338013 — 0.67 2.07e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
rs4574762 — 0.19 2.29e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs2371208 — — 2.6e-06 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs10493514 — — 2.8e-06 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
rs6504441 PRKCA 0.60 2.87e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs987839 SLCO1B1 — 3.19e-06 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
rs12413082 MSRB2 0.53 3.33e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs17205854 — — 3.74e-06 1364 — American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
rs17811551 ADAMTS6 — 3.74e-06 1364 — American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
rs1633063 — 0.68 3.82e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
rs3129063 — 0.67 4.33e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
rs513154 IMPG2 0.52 4.65e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs1582594 — 1.87 4.76e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
rs158869 — 1.37 4.98e-06 763 vs 1085 754 vs 850 German Mean age 99.7 — — Genome-Wide Association Study 21740922
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  • 25 of 147 variants