Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
rs1054016 TNFSF11 1.09 0.579 137 vs 213 — Korean Mean age 90 T — Genome-Wide Association Study 19641380
(rs429358, rs7412) + (rs2075650) APOE + TOMM40 0.93 0.337 403 vs 1670 3746 vs 5912 Dutch Mean age 94 e4 + G — Genome-Wide Association Study 21418511
rs1800802 MGP 0.77 0.132 137 vs 213 — Korean Mean age 90 C — Genome-Wide Association Study 19641380
rs2274471 JAK2 (for males) 1.58 0.088 137 vs 213 — Korean Mean age 90 — C Genome-Wide Association Study 19641380
9q31.3–34.2 — — 0.054 632 (total) — Caucasian By Expected age of death: Male 90-100, Female 95-104 — — Genome-Wide Association Study 20824210
Chromosome 4 at D4S1564 Chromosome 4 at D4S1564 — 0.044 303 — Human Minimum age 98 for one sibling (of sibship) — — Genome-Wide Association Study 11526246
marker D4S1564 — — 0.044 308 — European min. age 98 for one sibling. 91+ males, 95+ females — — Genome-Wide Association Study 11526246
3p24-22 3p24-22 — 0.037 3953 — American Minimum age 98 — — Genome-Wide Association Study 20824210
3p24.2–22.3 — — 0.037 632 (total) — Caucasian By Expected age of death: Male 90-100, Female 95-104 — — Genome-Wide Association Study 20824210
rs326146 ADCY2 1.46 0.024 137 vs 213 — Korean Mean age 90 — A Genome-Wide Association Study 19641380
rs4237973 PIK3C2G 1.51 0.022 137 vs 213 — Korean Mean age 90 — C Genome-Wide Association Study 19641380
- Telomere maintenance pathway (TM) — 0.02 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
rs3780223 C9orf94 1.10 0.012546995 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
rs155979 PCSK1 0.61 0.012 137 vs 213 — Korean Mean age 90 G — Genome-Wide Association Study 19641380
- Insulin signaling pathway (IIS) — 0.01 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
rs712700 — 1.87 0.01 137 vs 213 — Korean Mean age 90 — G Genome-Wide Association Study 19641380
rs4648884 RUNX3 — 0.00992 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
rs5771675 FAM19A5 — 0.00985 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
rs1205035 Intergenic — 0.00983 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
rs1834497 CLSTN2 — 0.00979 1173 vs 570 — American 85-100 — A Genome-Wide Association Study 22533364
rs4148544 ABCC4 — 0.00977 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
rs671 ALDH2 (for males) 2.11 0.009 137 vs 213 — Korean Mean age 90 — A Genome-Wide Association Study 19641380
rs2590504 KIAA0649 — 0.00854 1173 vs 570 — American 85-100 — C Genome-Wide Association Study 22533364
rs2232548 KLRF1 1.15 0.008366096 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
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  • 25 of 710 variants