Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2542052 APOC3 — 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
rs5882 CETP — 0.069 Centenarians (n = 213) their offspring (n = 216) vs 258 — Ashkenazi Jewish Mean age 98.2 A — — 16602826
rs769449 APOE 0.70 0.018 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German G — — 22234866
rs2069827 IL6 — 0.064 1,089 vs 736 563 (longtitudinal study) Danish, Dutch 92+ Danish, 85+ Dutch A — — 22234866
rs1061170 CFH 1.78 0.005 491 vs 0 — Finn — His — — 19000922
rs4420638 APOE 0.72 3.4e-36 7729 vs 16121 13060 vs 61156 European 90+ — — GWAS 24688116
rs2149954 — 1.10 1.74e-08 7729 vs 16121 13060 vs 61156 European 90+ — — GWAS 24688116
rs429358, rs7412 APOE — 0.009 1477 total — Italian 18-109 e4 non-e4 - 16896546
rs5882 CETP 3.56 0.001 213 vs 258 — Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
rs1800896 IL10 3.10 0.0003 142 vs 153 — Mean age 67 AA GG Candidate Region/Gene 15466015
rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
rs2476601 PTPN22 — 0.663 225 vs 278 — Italian Mean age 93 — — Candidate Region/Gene 21113673
rs1333049 — 0.64 0.001 80 (cases) vs 258 healthy young — Human 100–104 C — Candidate Region/Gene 20230275
rs1801133 MTHFR — 0.01 108 (patients with CVD) vs 118 — Swiss >65 C — Candidate Region/Gene 10583447
K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 Italian, Spaniard 100–111 K — Candidate Region/Gene 23354683
rs5882 CETP — 0.318 175 vs 189 — Italian 99.6 — — Candidate Region/Gene 15888337
rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
rs132793 XRCC6 — 0.74 224 vs 293 170 vs 220 Caucasian, European 90-103, 98+ (replication) — — Candidate Region/Gene 21972126
rs1042522 TP53 0.57 0.006 100 very old vs 280 old vs 189 young — Italian 91+, 73-91 P — Candidate Region/Gene 23125046
rs4646 CYP19 1.90 0.04 108 vs 85 — Italian 90+ — T Candidate Region/Gene 20819792
rs2234693 ESR1 — 0.08 108 vs 85 — Italian 90+ PP (genotype) — Candidate Region/Gene 20819792
rs1800795 IL6 — 0.006 244 vs 309 138 vs 98 Italian 85+ CC (genotype) — Candidate Region/Gene 19377912
rs1937 TFAM — 0.003 107 vs 284 — Spaniard 100–111 G CC (genotype) Candidate Region/Gene 23186209
rs10149689 TSHR 1.56 0.001 232 vs 163 — Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
rs12050077 TSHR 1.68 0.0001 232 vs 163 — Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
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  • 25 of 572 variants