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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs9282861 SULT1A1 0.017 68 vs 49 American, Caucasian 70-99 GG Candidate Region/Gene 9854023
APOE4 APOE 0.71 106 vs 349 American 70-79 (duration of study - 7 years) e4 Candidate Region/Gene 16799145
rs429358, rs7412 APOE 0.75 0.005 2307 vs 764 American, Danish Mean age 60.2 e4 e2 Candidate Region/Gene 23040522
rs2075650 TOMM40 0.70 0.002 2307 vs 764 American, Danish Mean age 60.2 G A Candidate Region/Gene 23040522
rs2075650 APOE 0.000527 1364 American, British Age range 50-108; mean age at death 80.2 C T Candidate Region/Gene 22445811
HRAS1 LASS1 (CGT) APOE 1.06e-09 68 vs 68 American Candidate Region/Gene 20569235
rs6669212 LMNA 0.041 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs1468772 LMNA 1.17 0.054 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs12063072 LMNA 0.36 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs4641 LMNA 0.5 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs12117552 LMNA 0.21 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs508641 LMNA 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs582690 LMNA 0.078 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs547915 LMNA 0.11 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs915179 LMNA 0.014 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs10737170 LMNA 0.11 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs4661146 LMNA 0.12 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs3814314 LMNA 0.017 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs429358, rs7412 APOE 0.0005 318 vs 350 376 vs 506 American, Caucasian Mean age 100,8 e4 e2 Candidate Region/Gene 18034366
rs2866164 MTP 0.024 318 vs 350 376 vs 506 American, Caucasian Mean age 100,8 GG Candidate Region/Gene 18034366
rs5882 CETP 1.30 0.041 318 vs 350 376 vs 506 American, Caucasian Mean age 100.8 non-GG GG Candidate Region/Gene 18034366
rs6686943 LMNA 0.51 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
3p24-22 3p24-22 0.037 3953 American Minimum age 98 Genome-Wide Association Study 20824210
rs987839 SLCO1B1 3.19e-06 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
rs17205854 3.74e-06 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
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