Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
REN polymorphism - mtDNA mtDNA 3.27 0.006 157 — Italian 100+ — REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
rs915179-rs2485662-rs4641-rs1468772 LMNA 1.56 2.5e-05 873 vs 443 New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) American, Caucasian Mean age 101.5 — GTCT Candidate Region/Gene 22340368
rs1800896 - rs1800629 IL10 — 0.038 174 vs 224 — Italian >100 — GG-GG (only in men) Candidate Region/Gene 12676903
rs1800591-rs61733139 MTTP — 0.61 197 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
HP*1 F/S HP 0.82 0.33 1072 total — Italian >88 — — Candidate Region/Gene 21147083
rs2234693 - rs2234693 ESR1 — 0.12 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
APOE polymorphism APOE — 0.437 1408 cases — Brazilian 69.3 +/- 7.2 — — Candidate Region/Gene 17934638
rs11279109 - APOB XbaI APOB — 0.001 191 (case) vs 53 (initial) — Chinese > 90 baseline, Mean age 97 +/- 3 — D - X+ Candidate Region/Gene 17393087
rs1061581 - rs1008438 - rs2227956 Hsp70Ba 0.55 0.015 168 cases — Danish Mean age 92.8 +/- 0.4 — G-C-T (haplotype) Candidate Region/Gene 20388090
HP1/2 common polymorphism HP — 0.05 200 (cases) vs 539 (initial) (initial) — Italian >88 — — Candidate Region/Gene 21703254
Haplogroup J — 0.38 0.025 98 vs 117 — Chinese 90–100 — — Candidate Region/Gene 18759861
rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.9852 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.1761 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.1282 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.8 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.1856 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.139 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
C4B1 C4B — 0.05 77 (cases) vs 235 — Italian Mean age 101 — — Candidate Region/Gene 10219002
rs1800591-rs61733139 MTTP — 0.93 164 vs 261 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.03972 184 vs 184 — Italian 100 A-G-G-A non A-G-G-A haplotypes Candidate Region/Gene 20126416
rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.02249 184 vs 184 — Italian 100 A-G-G-A-T-A non A-G-G-A-T-A haplotypes Candidate Region/Gene 20126416
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90+ apoE4 — Candidate Region/Gene 11780357
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
rs11279109 - SI000565Q APOB — 0.05 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 D - S D - M Candidate Region/Gene 17393087
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  • 25 of 53 variants