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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish Irish, Italian Italian 100.8 years, Irish 89.8 years Candidate Region/Gene 15050299
rs854560 PON1 1.0 579 vs 308 Italian Over 100 Candidate Region/Gene 12082503
192/55 loci PON1 0.01 579 vs 308 Italian Over 100 R+M+ Candidate Region/Gene 12082503
codon 192 PON1 1.0 192 vs 77 Italian 56 ages 66 to 89, 96 >90 Candidate Region/Gene 16799134
codon 55 PON1 1.0 192 vs 77 Italian 56 ages 66 to 89, 96 >90 Candidate Region/Gene 16799134
Not specified IL2 0.05 470 vs 120 Italian, Bulgarian Age range: 65-99 Candidate Region/Gene 21299522
Not specified IFNG 0.05 707 vs 339 Turkish, Polish, Italian, Bulgarian Age range: 65-99 Candidate Region/Gene 21299522
−1082 G/A IL10 0.025 190 vs 260 Italian >99 years old G Candidate Region/Gene 11857058
- HRAS1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes - 19367319
- SIRT3 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- TH 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- INS 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- IGF2 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4073591 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4073590 DEAF1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs11040489 KRTAP5-6 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4930001 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs800140 TSPAN32 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs16928120 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs189037 ATM 1.85 0.028 128 vs 150 Italian - 22960875
- TH 0.045 202 vs 170 vs 82 Italian 100-105 (oldest of 3 age groups, see notes) Candidate Region/Gene 11053670
rs28969505 YTHDF2 2.19 0.023 137 vs 412 Italian age 99–109,years, mean age 101 years; 26 men, 111 women Candidate Region/Gene 16799135
rs4073591 DEAF1 0.002618 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
rs4073590 DEAF1 0.004259 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
rs11040489 KRTAP5-6 0.005869 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
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