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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2288377 IGF1 1.0 485 vs 392 Chinese 94.92 Candidate Region/Gene 18761080
rs5742612 IGF1 1.0 485 vs 392 Chinese 94.92 Candidate Region/Gene 18761080
rs35767 IGF1 1.0 485 vs 392 Chinese 94.92 Candidate Region/Gene 18761080
rs17630266 FOXO1 1.0 761 vs 1056 350 vs 350 Chinese mean age 102.3 Candidate Region/Gene 19793722
many SNPs TH 0.05 1321 vs 1140 Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) Candidate Region/Gene 19367319
many SNPs IGF2 0.05 1321 vs 1140 Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) Candidate Region/Gene 19367319
many SNPs INS 0.05 1321 vs 1140 Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) Candidate Region/Gene 19367319
many SNPs HRAS1 0.05 1321 vs 1140 Italian Mean age 101.9 (southern Italian), 101.0 (northern-central Italian), 104.41 (German), 103.1 (French) Candidate Region/Gene 19367319
rs939915 SIRT3 0.0145 2461 samples (cases and controls combined) Italian Candidate Region/Gene 19367319
indel ACE1 0.05 82 vs 252 Italian Mean age 100 +/- 2 Candidate Region/Gene 12954489
Not specified IL2 0.05 470 vs 120 Italian, Bulgarian Age range: 65-99 Candidate Region/Gene 21299522
Not specified IFNG 0.05 707 vs 339 Turkish, Polish, Italian, Bulgarian Age range: 65-99 Candidate Region/Gene 21299522
Arg156Arg ERCC2 0.05 149 vs 413 Polish Mean age 101.1 Candidate Region/Gene 19707883
Asp312Asn ERCC2 0.05 149 vs 413 Polish Mean age 101.1 Candidate Region/Gene 19707883
rs4986790 TLR4 0.61 273 vs 594 German Mean age 97.9 Candidate Region/Gene 17493663
- HRAS1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes - 19367319
- SIRT3 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- TH 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- INS 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
- IGF2 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4073591 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4073590 DEAF1 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs11040489 KRTAP5-6 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs4930001 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319
rs800140 TSPAN32 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls French, German, Italian centenarians; see notes - 19367319