| polymorphism | factor | odds ratio | pvalue | initial number | replication number | Population | age of cases | shorter lived allele | longer lived allele | study type | reference |
| - | Insulin signaling pathway (IIS) | — | 0.01 | 403 vs 1670 | — | European | 90-103 | — | — | Genome-Wide Association Study | 22113349 |
| - | Telomere maintenance pathway (TM) | — | 0.02 | 403 vs 1670 | — | European | 90-103 | — | — | Genome-Wide Association Study | 22113349 |
| 3p24-22 | 3p24-22 | — | 0.037 | 3953 | — | American | Minimum age 98 | — | — | Genome-Wide Association Study | 20824210 |
| 192/55 loci | PON1 | — | 0.01 | 579 vs 308 | — | Italian | Over 100 | — | R+M+ | Candidate Region/Gene | 12082503 |
| GH1 "intron SNP" | GH1 | — | 0.019 | 866 | — | Dutch | Minimum age 85 | — | — | Candidate Region/Gene | 15771611 |
| Ile119Val | PCMT1 | — | 0.049 | 40 vs 40 | — | Ashkenazi Jewish | Mean age 87.2 | — | — | Candidate Region/Gene | 10496068 |
| IL10 haplotypes | IL10 | — | 0.05 | 60 vs 60 | — | Bulgarian | Age range: 65-99 | — | −1082G, −819C, -592C | Candidate Region/Gene | 21299522 |
| IL10 haplotypes | IL10 | — | 0.05 | 237 vs 90 | — | Turkish | Age range: 65-99 | — | −1082G, −819C, −592C | Candidate Region/Gene | 21299522 |
| TNF haplotypes | TNF | — | 0.01 | 60 vs 50 | — | Bulgarian | Age range: 65-99 | — | −1031 C/C, −863 C/A, −857 C/C, −308 G/G, +489 G/G | Candidate Region/Gene | 21299522 |
| KIR2DS3 haplotypes | KIR2DS3 | — | 0.05 | 100 vs 100 | — | Irish | Age range: 65-99 | — | — | Candidate Region/Gene | 21299522 |
| −1082 G/A | IL10 | — | 0.025 | 190 vs 260 | — | Italian | >99 years old | — | G | Candidate Region/Gene | 11857058 |
| DR7 | HLA-DRB1 | — | 0.01 | 325 centenarians versus 229 nonagenarian siblings | — | French | — | — | — | - | 9425225 |
| DR11 | HLA-DRB1 | — | 0.01 | 325 centenarians versus 229 nonagenarian siblings | — | French | — | — | — | - | 9425225 |
| DR13 | HLA-DRB1 | — | 0.01 | 325 centenarians versus 229 nonagenarian siblings | — | French | — | — | — | - | 9425225 |
| rs189037 | ATM | 1.85 | 0.028 | 128 vs 150 | — | Italian | — | — | — | - | 22960875 |
| F5 G1691A | F5 | — | 0.002 | 400 neonates (187 female and 312 male), 184 healthy adults (129 female and 55 male), and 432 long-lived individuals (343 women and 89 men). | — | Polish | >95 years versus 44 years | — | — | - | 20720309 |
| rs11188059 | CYP2C | — | 0.04 | 616 centenarians versus control group of 945 younger individuals | — | German | — | — | — | Candidate Region/Gene | 21798861 |
| HinfI347 | APOA4 | — | 0.05 | 71 vs 100 | — | Italian | mean102.3 years | — | — | Candidate Region/Gene | 9622284 |
| - | TH | — | 0.045 | 202 vs 170 vs 82 | — | Italian | 100-105 (oldest of 3 age groups, see notes) | — | — | Candidate Region/Gene | 11053670 |
| marker D4S1564 | — | — | 0.044 | 308 | — | European | min. age 98 for one sibling. 91+ males, 95+ females | — | — | Genome-Wide Association Study | 11526246 |
| rs28969505 | YTHDF2 | 2.19 | 0.023 | 137 vs 412 | — | Italian | age 99–109,years, mean age 101 years; 26 men, 111 women | — | — | Candidate Region/Gene | 16799135 |
| rs2153960 | FOXO3A | 1.16 | 0.019 | 300 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 115 | — | — | Candidate Region/Gene | 19489743 |
| rs3778588 | FOXO3A | 1.22 | 0.023 | 301 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 116 | — | — | Candidate Region/Gene | 19489743 |
| rs12153009 | GHR | 0.87 | 0.033 | 305 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 120 | — | — | Candidate Region/Gene | 19489743 |
| rs2940923 | GHR | 1.21 | 0.0013 | 306 vs 603;279 vs 797;383 vs 363 | — | Caucasian | 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 121 | — | — | Candidate Region/Gene | 19489743 |
