Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs28359172 MT-ND5 0.30 0.003 98 vs 117 — Chinese 90–100 G — Candidate Region/Gene 18759861
C150T mtDNA L2 — 1.0 556 vs. 403 — Chinese 90-108 — — Mitochondrial Haplogroup 21262335
mtDNA C150T — — 0.936 556 vs 403 — Chinese 90–108 (94.59±3.34) — — Candidate Region/Gene 21262335
rs189037 (genotype) ATM — 0.004 875 (280 m, 595 f) vs 886 (491 m, 395 f) — Chinese Mean age 94,6, healthy — CT (Article); GA (ENSEMBL) Candidate Region/Gene 20816691
rs189037 ATM — 0.004 875 vs 886 — Chinese mean 94.6 — CT Candidate Region/Gene 20816691
microsatellite polymorphism surrounded by rs2288377, rs5742612, and rs35767 IGF1 — 0.922 493 vs 425 — Chinese (females ≥ 94; males ≥ 90 — — Candidate Region/Gene 20199671
STR variation CSF1TPO — 0.003 60 vs 250 — Chinese >90 low variation in STRs high variation in STRs - 20582731
mtDNA haplogroups mtDNA 2.01 0.003 367 vs 371 — Chinese Mean age 94.4 non-F F Mitochondrial Haplogroup 21945877
rs429358 + rs7412 APOE — 0.04 1236 vs 326 — Chinese 60+ e4 non-e4 Candidate Region/Gene 9792194
rs2288377 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
rs5742612 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
rs35767 IGF1 — 1.0 485 vs 392 — Chinese 94.92 — — Candidate Region/Gene 18761080
rs17630266 FOXO1 — 1.0 761 vs 1056 350 vs 350 Chinese mean age 102.3 — — Candidate Region/Gene 19793722
rs2755209 FOXO1 0.80 0.0046 761 vs 1056 350 vs 350 Chinese mean age 102.3 C T Candidate Region/Gene 19793722
rs2755213 FOXO1 0.75 7.4e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 C T Candidate Region/Gene 19793722
rs2253310 FOXO3 1.35 7.9e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 C G Candidate Region/Gene 19793722
rs2802292 FOXO3 1.36 2.9e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 G T Candidate Region/Gene 19793722
rs4946936 FOXO3 1.40 1.8e-05 761 vs 1056 350 vs 350 Chinese mean age 102.3 T C Candidate Region/Gene 19793722
rs1061581 HSPA1B — 0.05 191 vs 53 — Chinese >90 A G Candidate Region/Gene 19840767
rs2227956 HSPA1L — 0.01 191 vs 53 — Chinese >90 TC TT/CC Candidate Region/Gene 19840767
rs1061581-rs1043618-rs2227956 — 4.51 0.016 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
rs1061581-rs1043618-rs2227956 — 3.46 0.025 191 vs 53 — Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
5178 adenine/cytosine ND2 — 0.363 95 vs 298 — Chinese 76.2±5.0 C — Candidate Region/Gene 12384792
mt5178A ND2 — 0.05 95 vs 105 — Chinese Mean age 76 — АА Candidate Region/Gene 12384792
1376G/T;1388G/A;95A/G;871G/A;1024C/T;1360C/T;392 G/T G6PD 6.30 0.013 173 total (see notes) — Chinese >80 — — Candidate Region/Gene 17077204