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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs4420638 APOC1 0.53 1.8e-10 763 vs 1085 754 vs 850 German Mean age 99.7 G Genome-Wide Association Study 21740922
rs4073591 DEAF1 0.002618 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
rs4073590 DEAF1 0.004259 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
rs11040489 KRTAP5-6 0.005869 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
rs4930001 DEAF1 0.010851 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
rs800140 TSPAN32 0.0081 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
rs16928120 0.00057 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
rs11188059 CYP2C 0.04 616 centenarians versus control group of 945 younger individuals German Candidate Region/Gene 21798861
rs769449 APOE 0.70 0.018 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German G 22234866
rs6911407 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs768023 FOXO3 1.27 0.007 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs2802288 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs2274776 FOXO3 0.95 0.536 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs1571631 FOXO3 0.99 0.872 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs2883881 FOXO3 0.77 0.1 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs12200646 FOXO3 1.28 0.064 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs2802290 FOXO3 1.26 0.01 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs13220810 FOXO3 0.78 0.02 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs7762395 FOXO3 1.38 0.005 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs9400239 FOXO3 1.38 0.0007 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs3800231 FOXO3 1.42 0.0002 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs1268170 FOXO3 1.24 0.02 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs473268 FOXO3 1.21 0.044 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs519007 FOXO3 0.93 0.55 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
rs479744 FOXO3 1.40 0.001 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
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  • 25 of 29 variants