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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs11136000 CLU 0.975 1364 American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
rs11767557 EPHA1 0.267 1364 American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
rs1485780 CD2AP 0.604 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
rs2075650 APOE 0.000527 1364 American, British Age range 50-108; mean age at death 80.2 C T Candidate Region/Gene 22445811
rs3764650 ABCA7 0.135 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
rs3818361 CR1 0.563 1364 American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
rs3851179 PICALM 0.227 1364 American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
rs3865444 CD33 0.442 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
rs610932 MS4A6A 0.176 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
rs744373 BIN1 0.689 1364 American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
apoE haplotypes 0.0042 3924 American 5-70 Apo e4 Candidate Region/Gene 21332925
APOE4 APOE 0.71 106 vs 349 American 70-79 (duration of study - 7 years) e4 Candidate Region/Gene 16799145
HRAS1 LASS1 (CCT) APOE 9.5e-05 204 vs 251 American Candidate Region/Gene 20569235
HRAS1 LASS1 (CCT) APOE 0.00197 125 vs 163 American Candidate Region/Gene 20569235
HRAS1 LASS1 (CCT) APOE 0.0511 68 vs 68 American Candidate Region/Gene 20569235
HRAS1 LASS1 (CGT) APOE 6.91e-07 204 vs 251 American Candidate Region/Gene 20569235
HRAS1 LASS1 (CGT) APOE 1e-06 79 vs 88 American Candidate Region/Gene 20569235
HRAS1 LASS1 (CGT) APOE 1.06e-09 68 vs 68 American Candidate Region/Gene 20569235
rs1043618 HSP70-A1A 1.0 347 vs 238 American, Ashkenazi Jewish Minimum age 100 Candidate Region/Gene 17027907
rs10737170 LMNA 0.11 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs12063072 LMNA 0.36 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs12117552 LMNA 0.21 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs1468772 LMNA 1.17 0.054 873 vs 443 (initial) New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 (replication) American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
rs2075650 TOMM40 0.70 0.002 2307 vs 764 American, Danish Mean age 60.2 G A Candidate Region/Gene 23040522
rs2275075 LMNA 0.54 873 vs 443 New England Centenarian Study: 545 vs 193; French: 557 vs 546; Southern Italian Centenarian Study: 455 vs 450; Ashkenazi Jewish: 354 vs 348 American, Caucasian Mean age 101.5 Candidate Region/Gene 22340368
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  • 25 of 46 variants