Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
(A/C)−110 HSP70-1 0.40 0.005 120 vs 471 — Italian 100 years and above A — Candidate Region/Gene 14501185
- HRAS1 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls 1 (specifically for SIRT3 in a French population) French, German, Italian centenarians; see notes — — - 19367319
- SIRT3 — 0.145 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
- TH — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
- INS — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
- IGF2 — 0.05 see notes; stratified by population; total = 1321 cases versus 1140 controls — French, German, Italian centenarians; see notes — — - 19367319
- TH — 0.045 202 vs 170 vs 82 — Italian 100-105 (oldest of 3 age groups, see notes) — — Candidate Region/Gene 11053670
- GSTM1 — 0.54 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
- GSTM1 — 0.74 94 vs 418 — Italian 100 years vs 46 years — — - 11162685
- CYP1A — 0.68 94 vs 418 — Italian 100 years vs 46 years — — Candidate Region/Gene 11162685
--1082G-->A IL10 — 0.0001 109 (oldest old men) vs 263 (healthy controls) — Italian >95 A — Candidate Region/Gene 15466015
-1377G/A FAS — 0.106 50 vs 86 — Italian 100.8 ± 1.8 (100 to 106) — — Candidate Region/Gene 11965496
-330T/G IL2 1.43 0.096 168 vs 214 — Italian >99 — — Candidate Region/Gene 16518704
-670A/G FAS — 0.608 50 vs 86 — Italian 100.8 ± 1.8 (100 to 106) — — Candidate Region/Gene 11965496
16 bp duplication in intron 3 (WT=no duplicaiton) TP53 — 0.59 66 vs 150 — Italian 100.19±2.2 (95-105) — — Candidate Region/Gene 15195682
192 (Q/R) PON1 1.30 0.007 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years Q — Candidate Region/Gene 15050299
192/55 loci PON1 — 0.01 579 vs 308 — Italian Over 100 — R+M+ Candidate Region/Gene 12082503
3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR) HRAS 1.13 0.002 234 vs 467 — Italian centenarians a3 allele (see notes) — Candidate Region/Gene 11943467
55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years — — Candidate Region/Gene 15050299
?145K LMP7 — 0.849 157 vs 311 — Italian 88+ K — Candidate Region/Gene 11772516
?60H LMP2 — 0.756 157 vs 311 — Italian 88+ H — Candidate Region/Gene 11772516
A-3826G (rs1800592) - C-3740A UCP1 0.81 0.014 236 vs 741 — Italian >91 G-A — Candidate Region/Gene 21827845
AAT M/Z/S AAT 0.18 1e-07 143 vs 255 vs 127 — Italian Centenarians M, S Z Candidate Region/Gene 17048073
ADA genotypes ADA — 0.003 62 vs 64 vs143 vs 272 — Italian Minimum age 90 ADA*2 non-ADA*2 Candidate Region/Gene 20174870
APOA1-MspI-RFLP A/P alleles APOA1 — 0.045 413 vs. 571 — Italian median age 101 A P Candidate Region/Gene 12556235
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